Tutti gli articoli di Claudio Seppi

Postdoc position in Protein signaling and cell division

A postdoctoral position is available at the Novo Nordisk Foundation Center for Protein Research (CPR–www.cpr.ku.dk ), University of Copenhagen.

About CPR and the research group
Novo Nordisk Foundation Center for Protein Research (CPR) at the Faculty of Health and Medical Sciences, University of Copenhagen, has been established to promote basic and applied discovery research on human proteins of medical relevance. The Center comprises a wide range of expertise and skills, from proteomics, bioinformatics, high-content microscopy, and high-throughput protein production for functional dissection of complex signaling systems.
The Nilsson group focuses on mechanisms of protein phosphatase substrate selection as well as the segregation of chromosomes during cell division. As protein phosphatases are major regulators of cell division these two topics are tightly connected.
The laboratory is equipped with the cutting-edge infrastructure for molecular biology, cell biology and biochemistry work. Our group is technically and internationally diverse and embedded in excellent environment for high-quality research and collaboration. The group consistently publishes in top-ranked journals and has outstanding track-record in training the next generation of researchers. We are now looking for a highly motivated and qualified postdoc candidate to join our research group.

Please find more information about the group here: http://www.cpr.ku.dk/research/proteinsignaling/nilsson/

Project description
The project will follow up on our recent discoveries (Hertz et al, Molecular Cell (2016) and Hein et al, Nature Cell Biology (2017) ) on the role of PP2A complexes in coordination of mitotic events and their role in chromosome segregation and spindle assembly checkpoint signaling. The aim is to dissect the underlying molecular mechanisms ensuring tight coordination of cellular signaling during cell division by integrating biochemical, cell based and imaging approaches.

Tentative start date: 1 June 2018.

Qualifications
The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good inter-personal and communication skills.
The candidates are required to have a PhD degree or equivalent in natural or medical science.
Excellent scientific track-record.
Expert knowledge in one or more of the following areas would be considered an advantage:
Analysis of cell signaling with biochemistry and molecular biology approaches.
Genetics and cell biology.
Live cell microscopy and analysis of cell division.
Good communication skills, both oral and written.
An analytical aptitude for devising innovative scientific or technical solutions.
Demonstrate enthusiasm, motivation, flexibility and confidence.
Place of employment and work
The employment is at CPR (www.cpr.ku.dk ), University of Copenhagen, located in central Copenhagen. The research environment at CPR is ambitious and international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories, supercomputer resources and state-of-the-art facilities within protein science, including microscopy, cryo-EM, and the next generation sequencing. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center. For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and www.workingconditions.ku.dk

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is around 33,200-34,900 DKK plus 17.1 % in pension contribution.
The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension will be paid out as salary. For more information about the different pension schemes www.ism.ku.dk/onarrival/pension/

Duration: The duration of the positions is 1 year with a possible extension for up-to 3 years (depending on the performance, and previous employment at the University of Copenhagen).

Application procedure
Your application should be submitted electronically by clicking on “apply now” below.

Your application should include the following documents:
Cover letter
Curriculum vitae, incl. educational qualifications, experience and a list of publications.
A scanned copy of the final degree (PhD or equivalent) certificate. If the degree is not awarded, it is sufficient to mention when the applicant expects to submit thesis, or receive the qualifying degree
Names and contact details for 2-3 referees
The applicants can submit these materials in the given fields in the online submission system, or the application documents can be combined and submitted as a single PDF file. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements and that do not have a least one publication as first author.

Deadline for application: 6 th of April , 2018

After the expiry of the application deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at www.employment.ku.dk

For further information about the position or the process or if you experience any technical difficulty with the online submission system, please contact SUND HR: sund-hr-cpr@sund.ku.dk

CPR and the University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

Celiachia: studio UNIPV descrive il coinvolgimento di un importante processo cellulare nella degradazione della componente tossica del glutine

È stato appena pubblicato dalla rivista scientifica International Journal of Molecular Sciences un articolo intitolato “The in vitro effects of enzymatic digested gliadin on the functionality of the autophagy process” che per la prima volta descrive il coinvolgimento del processo autofagico della cellula nel contesto della celiachia.
Il lavoro firmato da Federico Manai e dal gruppo di ricerca del Dipartimento di Biologia e Biotecnologie dell’Università di Pavia, coordinato da Sergio Comincini e in collaborazione con Mauro Bozzola del Dipartimento di Medicina Interna e Terapia Medica dello stesso Ateneo, dimostra come, in un modello cellulare che mima la struttura dell’epitelio intestinale umano, la componente citotossica della gliadina possa essere significativamente ridotta modulando farmacologicamente il processo autofagico della cellula.

per saperne di più

Pre-iscrizione percorso PF24

Formazione iniziale, tirocinio e inserimento nella funzione docente

In Attesa della pubblicazione del bando, l’ateneo avvia una fase di ricognizione circa il numero di studenti interessati all’iscrizione al percorso PF24 presso l’Università degli Studi di Pavia.
La procedura ed i tutorial per la registrazione e la compilazione sono reperibili alla pagina web
http://www.unipv.eu/site/home/didattica/post-laurea/formazione-docenti.html

Posizione di Post-Doc presso l’Istituto dei Tumori Milano

Project Title: Detrimental effect of anti-PD-1 antibody treatment on tumor growth: role of innate immune and stromal cells?

We are seeking to recruit a post-doctoral fellow to conduct a project on Tumor Immunology/Immunotherapy at the Department of Biomedical Sciences for Health/Fondazione IRCCS – Istituto Nazionale dei Tumori  Molecular Targets Unit in Milan. We are looking for a highly motivated researcher to join our group.

Topic of the research: Programmed Death-1 (PD-1), a member of the CD28 receptor family, is reported to be expressed by activated T lymphocytes. This receptor is known to inhibit T cell activity upon its interaction with its ligands, PD-L1 and -L2. The PD-1/PD-Ls pathway is a crucial self-tolerance pathway that tumor cells hijack to escape immune elimination. Drugs designed to block PD-1 “release the brakes” on anti-tumor immunity, enabling endogenous effector mechanisms. Clinical studies with antibodies targeting PD-1 demonstrated that blocking the PD-1/PD-Ls interaction produced objective responses in a wide spectrum of solid and hematologic malignancies. However, it is now emerging that a fraction of patients become “hyperprogressors” after PD-1 blocking therapy with a greatly accelerated rate of tumor growth and clinical deterioration. The cellular and molecular mechanisms of this phenomenon have not been elucidated yet. The research goal is dedicated to the investigation of the molecular and cellular bases of this phenomenon.

Duration of fellowship: 3 years (renewal each year)

Candidate requirements include Ph.D, a high degree of motivation in academic research and a good ability to work independently. Skills in cellular and molecular biology/immunology are required. Experience with mouse preclinical models is desirable.

Please send a CV to Dr. Michele Sommariva at the following email address: michele.sommariva@unimi.it

Postdoctoral positions in genome stability at the Dunn School of Pathology, University of Oxford

Applications are invited for two Postdoctoral Research Associates to join Dr Dragana Ahel’s group at the Dunn School of Pathology. The main research area of Dragana Ahel’s laboratory is studying cellular pathways that maintain genome stability and play roles in human disease. The laboratory uses a multidisciplinary approach to study relevant protein factors at a biochemical, cellular, and physiological level. More information about the Ahel laboratory is available on the group’s website http://ahel-d.path.ox.ac.uk/.

The posts will be held at the Dunn School of Pathology, a world-class biomedical research Department at the University of Oxford. The Dunn School is based on the vibrant South Parks Road Science Campus in the heart of Oxford. Its research benefits from exceptionally strong scientific community and outstanding facilities.

Two positions are currently available: one suitable for candidates with the background in cell biology and genetics, and another for candidates with expertise in biochemistry and structural biology. Applicants should have a PhD in cell biology, biochemistry, or a related field, and a track record of publishing at an internationally-competitive level. Required skills include high level of competence in general molecular biology techniques, cell biology, protein biochemistry, genetics or protein crystallography. Experience in DNA repair, DNA replication, and broader area of genome stability would be an advantage, but is not necessary.

If you have an excellent background in biomedical sciences and a strong publication record, we want to hear from you!

For further details please visit:https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form


The closing date for applications is Friday 16 February 2018. Interviews will be held as soon as possible
thereafter. For informal enquires please contact Dragana Ahel via email dragana.ahel@path.ox.ac.uk

Career in Neurobiology

Seminari di Neurobiologia
Carieer day in Neurobiology
Giornata dedicata agli studenti della LM di Neurobiologiai, in cui sei ex studenti di Neuobiologia che ora lavorano nell’industria oppure in campo accademico (in Italia o all’estero), racconteranno il loro percorso formativo con i problemi incontrati, il loro attuale lavoro ed il loro grado di soddisfazione.
Nel pomeriggio, una di loro, Giulia Quattrocolo, parlerà di quello avrebbe voluto sapere quando era studentessa di Neurobiologia  (es. come accedere a borse di studio, a dottorati all’estero, come cercare una posizione di  postdoc, come si prepara un’application, come si scrive un Personal Statement etc.).

Saranno poi tutti disponibili a rispondere, in modo del tutto informale, alle auspicate domande.

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